MesoReefDAO is an initiative focused on regenerating coral reef ecosystems, incubated in the Mesoamerican Reefs and eager to scale worldwide. Its Regen Reef project will offer a holistic solution by combining decentralized science, marine biotechnology, and community-led innovation to regenerate coral reefs and human communities. It leverages blockchain for transparent funding and data sharing, uses IoT for real-time monitoring, and applies AI to scale coral and fish restoration through modular wetlabs, while contributing to developing a new, regenerative blue economy. Ideal customers/users, eco-conscious investors, research institutions, conservationists, and affected communities, seek measurable reef health improvements with transparent resource use and progress tracking. With coral reefs under threat, blockchain and Web3 allow global, accountable participation, aligning with DeSci’s rise for open, collaborative conservation.