Cryoprotective Agents (CPAs) and CPA solutions are essential elements of the cryopreservation process of biological materials, helping prevent damage caused by ice crystal formation at low temperatures. However, there isn’t a currently known compound that does this perfectly, yet. The discovery of new CPAs is therefore fundamental in advancing the field. It is a complex process that involves a combination of biological understanding, chemical synthesis, and rigorous testing.

There is currently no central repository of all known CPAs and data on their mechanisms of action and limitations, hindering scientists and medicinal chemists in the discovery of new, and review of existing CPAs.

This proposal aims to fund a project that will:

-Design, build, and publish the first modern, dynamically updated, searchable CPA repository, owned by CryoDAO

-Create the first IP-NFT in the DeSci ecosystem from a fully internally funded and implemented project, with no third parties involved

In line with the provisions in the CryoDAO Constitution (CRYO-7), this would be our first internally incubated scientific effort, resulting in a research tool that would enable faster progress in cryobiology, cryopreservation, and related fields.

It’s important to note that before writing this proposal, we sought feedback on the idea of a repository from several scientists in the cryobiology field, all of whom have confirmed that there is a significant market need for this solution. In addition to cryobiology, there are other markets where CPAs are incredibly important, such as aircraft ($1.17 billion, 5% CAGR globally) and road de-icing ($1.5 billion, 4% CAGR globally); frost damage mitigation for crops ($1.2 billion, 6% CAGR globally), and anti-aging skincare cosmetics ($42 billion, 6% CAGR globally).

Private companies in these fields have historically been willing to pay for tools that enable even minimal incremental advances, thus opening the potential for this project to eventually greatly contribute to our Treasury sustainability, should our DAO Members decide to expand it into offering paid, customized access to users. Access to technical databases may be priced at tens of thousands of dollars.